![]() ![]() Silver ion concentration in wound exudate rises over several daysĮvaluate effectiveness of polyurethane versus silver-coated polyurethane NPWT sponges at reducing MRSA colony counts The questions that we sought to answer were:Įvaluate silver ion elution from silver-coated polyurethane NPWT sponge Our purpose in this study was to evaluate the existing evidence on the use of silver in wound care. 45 It is imperative, therefore, that guidelines be developed on the proper use of silver-containing dressings. 1, 16, 17 Injudicious use of silver-containing dressings can lead to impaired wound healing. While the silver ion has great antimicrobial and bactericidal properties, it is also toxic to fibroblasts when present in high concentration. These novel dressings release silver ions into the wound in a sustained fashion. More recently, dressing with nanocrystalline silver has been developed. Silver sulfadiazine (SSD) is a very widely used silver formulation, especially in burns. ![]() The past few decades have seen a renewed interest in silver as a topical antimicrobial agent. 4 For this reason, resistance against the silver ion has only rarely been reported. 2 Ag + binds to DNA, RNA, and various proteins, leading to cell death via multiple mechanisms, 3 such as protein and nucleic acid denaturation, increased membrane permeability, and poisoning of the respiratory chain. 1 While silver metal (Ag) has no medicinal activity, silver ion (Ag +) has a broad antimicrobial spectrum, and is cytotoxic to bacteria, viruses, yeast, and fungi. The usefulness of silver for wound treatment has been known since 69 B.C. ![]()
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